Enoxaparin Sodium
Enoxaparin Sodium is a low-molecular-weight heparin (LMWH) anticoagulant. It works by accelerating the activity of antithrombin III, which inhibits clotting factors Xa and IIa, thereby preventing the formation and propagation of blood clots.
Dosage by Body Weight
Dosage is highly individualized and must be adjusted based on the patient's clinical indication, body weight, and renal function. It is administered via deep subcutaneous injection or intravenous injection (for specific cardiac indications only); it must not be given intramuscularly.
- Body Weight
- Below 5 kg
- Dose
- 1.5 mg/kg (neonates under 2 months) or 1 mg/kg (infants older than 2 months)
- Frequency
- Every 12 hours
- Tracking Notes
- Requires strict supervision by a pediatric specialist and frequent monitoring of anti-Factor Xa levels.
- Body Weight
- 5-7 kg
- Dose
- 1 mg/kg
- Frequency
- Every 12 hours
- Tracking Notes
- For therapeutic anticoagulation. Dose should be reduced for prophylaxis or in cases of severe renal impairment.
- Body Weight
- 8-10 kg
- Dose
- 1 mg/kg
- Frequency
- Every 12 hours
- Tracking Notes
- Administer subcutaneously in the abdomen or anterolateral thigh. Rotate injection sites.
- Body Weight
- 11-15 kg
- Dose
- 1 mg/kg
- Frequency
- Every 12 hours
- Tracking Notes
- Regularly monitor platelet counts and assess for any signs of bleeding or bruising.
- Body Weight
- 16-20 kg
- Dose
- 1 mg/kg
- Frequency
- Every 12 hours
- Tracking Notes
- Ensure dose adjustment if renal clearance (CrCl) is less than 30 mL/min.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 1.5 mg/kg (neonates under 2 months) or 1 mg/kg (infants older than 2 months) | Every 12 hours | Requires strict supervision by a pediatric specialist and frequent monitoring of anti-Factor Xa levels. |
| 5-7 kg | 1 mg/kg | Every 12 hours | For therapeutic anticoagulation. Dose should be reduced for prophylaxis or in cases of severe renal impairment. |
| 8-10 kg | 1 mg/kg | Every 12 hours | Administer subcutaneously in the abdomen or anterolateral thigh. Rotate injection sites. |
| 11-15 kg | 1 mg/kg | Every 12 hours | Regularly monitor platelet counts and assess for any signs of bleeding or bruising. |
| 16-20 kg | 1 mg/kg | Every 12 hours | Ensure dose adjustment if renal clearance (CrCl) is less than 30 mL/min. |
Formulation
Purpose
Prevention and treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), prevention of ischemic complications in unstable angina and non-Q-wave myocardial infarction, and treatment of acute ST-segment elevation myocardial infarction (STEMI).
Generic Name
Enoxaparin SodiumBranded Drug Names
Enoxaparin Sodium is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.